Intravitreal bevacizumab treatment for exudative age-related macular degeneration with good visual acuity.

To investigate the effect of intravitreal bevacizumab on the visual and anatomic outcome of patients with exudative age-related macular degeneration presenting with good visual acuity (VA).
A file review was performed for all consecutive patients with newly diagnosed exudative age-related macular degeneration and initial VA of ≥ 20/40 treated in 2005 to 2010 and followed for at least 6 months. Treatment consisted of 3 loading doses of intravitreal bevacizumab every 6 weeks and was repeated when fluid or hemorrhage was present.
The cohort included 130 patients (150 eyes). Mean follow-up was 20.2 ± 13.2 months, and mean number of injections was 11.3 ± 6.2. At the last examination, VA was stable or improved in 106 eyes (70.7%); 11 eyes (7.3%) lost ≥ 3 lines. Mean logarithm of the minimum angle of resolution VA measured 0.22 ± 0.1 (0-0.3) at presentation and 0.22 ± 0.2 (0-1.3) at the last visit. Corresponding values for central macular thickness were 267 ± 75 μm (137-562) and 226 ± 75 μm (75-568) (P = 0.14). The most frequent complication (18 eyes, 12%) was corneal epithelial defects.
Prompt intravitreal bevacizumab treatment for newly diagnosed exudative age-related macular degeneration in patients with good initial best-corrected visual acuity is associated with sustained or improved vision and a good safety profile. Attempts should be made to expedite the access of these patients to treatment, regardless of initial VA.
AuthorsRuth Axer-Siegel, Elite Bor, Dan H Bourla, Dov Weinberger, Karin Mimouni
JournalRetina (Philadelphia, Pa.) (Retina) Vol. 32 Issue 9 Pg. 1811-20 (Oct 2012) ISSN: 1539-2864 [Electronic] United States
PMID22825407 (Publication Type: Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab
  • Aged
  • Aged, 80 and over
  • Angiogenesis Inhibitors (administration & dosage, adverse effects)
  • Antibodies, Monoclonal, Humanized (administration & dosage, adverse effects)
  • Bevacizumab
  • Exudates and Transudates
  • Female
  • Follow-Up Studies
  • Humans
  • Intraocular Pressure (drug effects)
  • Intravitreal Injections
  • Male
  • Middle Aged
  • Retina (pathology)
  • Retreatment
  • Retrospective Studies
  • Tonometry, Ocular
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors)
  • Visual Acuity (physiology)
  • Wet Macular Degeneration (drug therapy, physiopathology)

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