Abstract | INTRODUCTION/OBJECTIVE: MATERIALS AND METHODS: 45 patients with lower urinary tract symptoms caused by benign prostatic hyperplasia used tamsulosin 0.4 mg over the course of 12 weeks; their International Prostate Symptom Score (IPSS) value was > or =8 points, while their Quality of Life Index (QLI) value was > or =3 points. Checkups were scheduled 4 and 12 weeks following the initiation of treatment, during which the values for IPSS and disease-specific quality of life (QLI) were obtained. RESULTS: At the beginning of tamsulosin treatment, the total IPSS was 24.95 points. After the 4- and 12-week checkups, the total IPSS fell to 16.09 and 11.20 points, respectively. The reduction in symptoms, quantified through IPSS, was 35.51% after 4 weeks of treatment, and 55.11% after 12 weeks. The Quality of Life Index was initially 4.49 points, it decreased to 2.49 points after 4 weeks, and to 1.40 points after 12 weeks, marking an improvement of 44.54% after 4 weeks and 68.82% after 12 weeks. There was a statistically significant difference between the initial values for IPSS and QLI and their values after both checkups (p < 0.05). Side effects were observed in three patients (6.66%), with one (2.22%) experiencing problems with ejaculation and the other two (4.44%) having vasodilatatory effects such as vertigo and headache. CONCLUSION: Clinical response to a 12-week tamsulosin treatment improved during the course of treatment, reflected in a reduction in all of the lower urinary tract symptoms, with rare and insignificant side effects.
|
Authors | Snjezana Milicevic, Radojka Bijelic |
Journal | Medical archives (Sarajevo, Bosnia and Herzegovina)
(Med Arch)
Vol. 66
Issue 3
Pg. 173-6
( 2012)
ISSN: 0350-199X [Print] Bosnia and Herzegovina |
PMID | 22822617
(Publication Type: Journal Article)
|
Chemical References |
- Adrenergic alpha-Antagonists
- Sulfonamides
- Tamsulosin
|
Topics |
- Adrenergic alpha-Antagonists
(adverse effects, therapeutic use)
- Aged
- Humans
- Male
- Middle Aged
- Prostatic Hyperplasia
(drug therapy)
- Sulfonamides
(adverse effects, therapeutic use)
- Tamsulosin
- Treatment Outcome
|