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Prolonged excretion of 7-aminoclonazepam in urine after repeated ingestion of clonazepam: a case report.

Abstract
Urinary analyses of the metabolite 7-aminoclonazepam (7-AC) can be helpful in monitoring drug abuse and in the context of suspected drug-facilitated sexual assaults (DFSA). Only two studies have reported detection times of 7-AC in urine after a single dose of clonazepam, and no previous studies have reported detection times after repeated ingestions of clonazepam. This report describes along detection time of 7-AC in urine in the case of a 28-year-old woman with a two year history of daily drug abuse of heroin and clonazepam, who was admitted to a detoxification unit. Urinary samples were delivered every morning for 9 days. Screening analysis in urine was performed by immunoassay, and confirmation analysis by LC-MS/MS. 7-AC was detected for 9 days, and the concentration at day 9 was still high (97 ng/ml), compared to previously reported data. These results indicate that after repeated ingestions of clonazepam, 7-AC can possibly be detected for about 2-3 weeks after cessation, applying cut-off levels commonly used in drug testing programs and DFSA cases.
AuthorsL W Storhaug, A Enger, K Hjelmeland, E L Øiestad, V Vindenes
JournalForensic science international (Forensic Sci Int) Vol. 222 Issue 1-3 Pg. e33-5 (Oct 10 2012) ISSN: 1872-6283 [Electronic] Ireland
PMID22819278 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • GABA Modulators
  • 7-aminoclonazepam
  • Clonazepam
Topics
  • Adult
  • Chromatography, Liquid
  • Clonazepam (administration & dosage, analogs & derivatives, urine)
  • Female
  • Forensic Toxicology
  • GABA Modulators (administration & dosage, urine)
  • Heroin Dependence
  • Humans
  • Mass Spectrometry
  • Substance-Related Disorders (urine)

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