Abstract |
Experiments on male albino rats were carried out in order to study the effects of diazepam and medazepam on the clonic-tonic convulsions in kindling phenomena evoked by multiple injections of a subconvulsive dose (40 mg/kg) pentylenetetrazol (PTZ). In the two doses used, both diazepam (0.25 and 1.0 mg/kg) and medazepam (2.0 and 5.0 mg/kg) manifest a marked anticonvulsive effect on the clonic-tonic convulsions in PTZ-kindled rats, with a marked dose-effect dependence. The evidence in the literature that the hippocampus plays the role of a pathologically determining structure in the realization of the PTZ kindling and that neurotransmission in the inhibitory synapses in the hippocampus is achieved by gamma-aminobutyric acid (GABA), gives grounds to accept that the anticonvulsive effects of diazepam and medazepam, observed in PTZ kindling, occur through GABA-ergic mechanisms, because the facilitating effect of benzodiazepines on the GABA-ergic neurotransmission is well known.
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Authors | M Lazarova-Bakarova, V V Petkov, M Genkova-Papasova |
Journal | Acta physiologica et pharmacologica Bulgarica
(Acta Physiol Pharmacol Bulg)
Vol. 16
Issue 2
Pg. 37-41
( 1990)
ISSN: 0323-9950 [Print] Bulgaria |
PMID | 2281800
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Medazepam
- Diazepam
- Pentylenetetrazole
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Topics |
- Animals
- Diazepam
(pharmacology)
- Dose-Response Relationship, Drug
- Electroencephalography
- Kindling, Neurologic
(drug effects)
- Male
- Medazepam
(pharmacology)
- Pentylenetetrazole
(antagonists & inhibitors)
- Rats
- Rats, Inbred Strains
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