Somatostatin-like immunoreactivity in the CSF of patients with dementia associated with alcoholism.

Abstract

Cerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for 9 patients with chronic alcohol ingestion and dementia associated with alcoholism and for 8 age-equivalent controls. The CSF SLI was significantly reduced (32%) in the alcoholics with dementia as compared to the controls. This finding is in accordance with previous observations on the relationship between reduced CSF SLI and cognitive impairment in various neuropsychiatric disorders, and extends this finding to patients with dementia associated with alcoholism.

• Authors: H Koponen, K J Reinikainen, J T Jolkkonen, P J Riekkinen
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 82 Issue 5 Pg. 289-91 (Nov 1990) ISSN: 0001-6314 [Print] Denmark
• PMID: 2281744 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptides
• somatostatin-like peptides

Topics

• Aged
• Alcoholism (cerebrospinal fluid, diagnosis)
• Dementia (diagnosis, psychology)
• Female
• Humans
• Liver Diseases, Alcoholic (cerebrospinal fluid)
• Male
• Mental Status Schedule
• Middle Aged
• Neuropsychological Tests
• Peptides (cerebrospinal fluid)