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New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine.

Abstract
New adamantane derivatives with amino acid residues and other bifunctional compounds were synthesized and their antiviral activity towards influenza A(H1N1)pdm and A(H3N2) viruses was studied. Some of these adamantane derivatives completely suppressed replication of remantadine-resistant influenza A virus strains.
AuthorsV A Shibnev, T M Garaev, M P Finogenova, E S Shevchenko, E I Burtseva
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 2 Pg. 233-5 (Jun 2012) ISSN: 1573-8221 [Electronic] United States
PMID22816091 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Rimantadine
  • Adamantane
Topics
  • Adamantane (analogs & derivatives, pharmacology)
  • Antiviral Agents (pharmacology)
  • Drug Resistance, Viral
  • Influenza A Virus, H1N1 Subtype (drug effects)
  • Influenza A Virus, H3N2 Subtype (drug effects)
  • Rimantadine (pharmacology)

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