Abstract | BACKGROUND: Although an association between the apolipoprotein E ( APOE) ε4 allele and increased risk of Alzheimer's disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. METHODS: RESULTS: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non- APOE ε4 carriers. The APOE ε4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. CONCLUSIONS: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
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Authors | Xiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachman |
Journal | American journal of Alzheimer's disease and other dementias
(Am J Alzheimers Dis Other Demen)
Vol. 27
Issue 5
Pg. 315-20
(Aug 2012)
ISSN: 1938-2731 [Electronic] United States |
PMID | 22815080
(Publication Type: Journal Article)
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Chemical References |
- Apolipoprotein E4
- Apolipoproteins E
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Topics |
- Age of Onset
- Aged
- Alzheimer Disease
(diagnosis, genetics)
- Apolipoprotein E4
(genetics)
- Apolipoproteins E
(genetics)
- Cognition Disorders
(diagnosis, genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Sensitivity and Specificity
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