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APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment.

AbstractBACKGROUND:
Although an association between the apolipoprotein E (APOE) ε4 allele and increased risk of Alzheimer's disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation.
METHODS:
Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review.
RESULTS:
Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non-APOE ε4 carriers. The APOE ε4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity.
CONCLUSIONS:
The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
AuthorsXiaoyan Sun, Joyce Nicholas, Aljoeson Walker, Mark T Wagner, David Bachman
JournalAmerican journal of Alzheimer's disease and other dementias (Am J Alzheimers Dis Other Demen) Vol. 27 Issue 5 Pg. 315-20 (Aug 2012) ISSN: 1938-2731 [Electronic] United States
PMID22815080 (Publication Type: Journal Article)
Chemical References
  • Apolipoprotein E4
  • Apolipoproteins E
Topics
  • Age of Onset
  • Aged
  • Alzheimer Disease (diagnosis, genetics)
  • Apolipoprotein E4 (genetics)
  • Apolipoproteins E (genetics)
  • Cognition Disorders (diagnosis, genetics)
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Retrospective Studies
  • Sensitivity and Specificity

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