[Prognostic value of MACC1 and c-met expressions in non-small cell lung cancer].

Abstract

BACKGROUND:

It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC).

METHODS:

MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry.

RESULTS:

MACC1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue (P<0.001). MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages (P<0.05) of NSCLC, but not with sex, age, smoking, and histological classification (P>0.05). In addition, a positive correlation between MACC1 and c-met expressions was observed (r=0.403, P<0.001). The result from the Kaplan-Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions (P<0.05). The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC (P=0.026).

CONCLUSIONS:

MACC1 and c-met have an important function in the differentiation, invasion, and metastasis of NSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC.

• Authors: Xingsheng Hu, Xi Fu, Shimin Wen, Xinyi Zou, Yusong Liu
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 15 Issue 7 Pg. 399-403 (Jul 2012) ISSN: 1999-6187 [Electronic] China
• PMID: 22814258 (Publication Type: Journal Article)

Chemical References

• MACC1 protein, human
• Trans-Activators
• Transcription Factors
• Proto-Oncogene Proteins c-met

Topics

• Carcinoma, Non-Small-Cell Lung (diagnosis, genetics, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (diagnosis, genetics, pathology)
• Male
• Middle Aged
• Prognosis
• Proto-Oncogene Proteins c-met (metabolism)
• Regression Analysis
• Survival Analysis
• Trans-Activators
• Transcription Factors (metabolism)