[Depin-E in the treatment of hypertensive crises in patients with essential and secondary arterial hypertension].

Abstract

Hypertonic crises were treated in 42 patients with the aid of depin-E, a new drug belonging to the nifedipine group. There were 35 patients with essential hypertension and 7 with secondary arterial hypertension. The initial drug dose was 10 mn (1 capsule) given sublingually. If necessary the drug was indicated again after 20 minutes, the dose being the same. The hypotensive treatment turned out to be highly effective in 37 patients (80%). Of these, 18 patients manifested the drug efficacy after intake of 10 mg, 19 after intake of 20 mg of the drug. In contrast to other nifedipines, depin-E is marked by rapid hypotensive action, pronounced diuretic effect and good tolerance. The hypotensive effect of the drug determined by primarily peripheral vasodilatation did not depend on the types of the central hemodynamics.

• Authors: T N Breskina, A B Demidova, G V Konoshenok, I V Chinilina
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 62 Issue 9 Pg. 64-7 ( 1990) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Depin-E v lechenii gipertonicheskikh krizov u bol'nykh éssentsial'noĭ i vtorichnoĭ arterial'noĭ gipertonieĭ.
• PMID: 2281409 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Calcium Channel Blockers
• Depin-E
• Nifedipine

Topics

• Adult
• Aged
• Antihypertensive Agents (therapeutic use)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (therapeutic use)
• Drug Evaluation
• Female
• Humans
• Hypertension (complications, drug therapy, etiology, physiopathology)
• Male
• Middle Aged
• Nifedipine (adverse effects, analogs & derivatives, pharmacology, therapeutic use)
• Time Factors