Abstract | BACKGROUND & AIMS: METHODS: We performed a randomized, double-blind, placebo-controlled, crossover study of 17 patients (13 women; mean age, 38.5 ± 2.4 years). The study included 2 treatment periods of 4 weeks each, separated by a 2-week washout period. In the first period, 7 participants were given buspirone (10 mg, 3 times daily for 4 weeks) and 10 were given placebo 15 minutes before meals; patients switched groups for the second period. We assessed meal-related symptoms and severity, along with gastric sensitivity, accommodation, and emptying (by using barostat and breath tests) before and after 4 weeks of treatment. RESULTS:
Buspirone significantly reduced the overall severity of symptoms of dyspepsia (7.5 ± 1.3 vs 11.5 ± 1.2 for placebo; P < .005) and individual symptoms of postprandial fullness, early satiation, and upper abdominal bloating, whereas placebo had no significant effect (all P < .05). Buspirone did not alter the rate of gastric emptying of solids or sensitivity to gastric distention, but it significantly increased gastric accommodation, compared with placebo (229 ± 28 vs 141 ± 32 mL, respectively; P < .05), and delayed gastric emptying of liquids (half-life = 64 ± 5 vs 119 ± 24 minutes, respectively). Adverse events were similar when patients were given buspirone or placebo. CONCLUSIONS: In patients with FD, 4 weeks of administration of buspirone significantly improved symptoms and gastric accommodation, compared with placebo, whereas gastric emptying of liquids was delayed.
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Authors | Jan Tack, Pieter Janssen, Tatsuhiro Masaoka, Ricard Farré, Lukas Van Oudenhove |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 10
Issue 11
Pg. 1239-45
(Nov 2012)
ISSN: 1542-7714 [Electronic] United States |
PMID | 22813445
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Gastrointestinal Agents
- Placebos
- Buspirone
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Topics |
- Adult
- Aged
- Buspirone
(administration & dosage)
- Cross-Over Studies
- Double-Blind Method
- Dyspepsia
(drug therapy, pathology, physiopathology)
- Female
- Gastric Emptying
(drug effects)
- Gastrointestinal Agents
(administration & dosage)
- Humans
- Male
- Middle Aged
- Placebos
(administration & dosage)
- Treatment Outcome
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