Abstract |
This clinical trial tested the effect of daily application of 10% w/v calcium phosphopeptide- amorphous calcium phosphate ( CPP-ACP) paste for 1 yr when added to regular toothbrushing with fluoridated toothpaste to prevent dental caries in pre-school children. High-caries-risk children aged 2½ to 3½ yrs in a suburban area of central Thailand were assigned to receive either CPP-ACP (n = 150) or a placebo control (n = 146) in addition to fluoridated toothpaste. The International Caries Detection and Assessment System (ICDAS) was recorded at baseline, 6 mos, and 1 yr. At 1 yr, a significant increase in mean numbers of enamel and dentin caries lesions, as well as dmfs, was found in both groups (p < 0.001). No significant difference was observed between groups on these 3 outcome measures (p = 0.23, 0.84, and 0.91, respectively). The odds of enamel caries lesion transitions to a state of regression or stability, compared with progression from baseline, was also not different between groups [OR = 1.00, 95% CI (0.86, 1.17)]. This trial found that daily application of 10% w/v CPP-ACP paste on school days for 1 yr, when added to regular toothbrushing with a fluoride toothpaste, had no significant added effect in preventing caries in the primary dentition of these pre-school children (ClinicalTrials.gov number CT01 604109).
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Authors | T Sitthisettapong, P Phantumvanit, C Huebner, T Derouen |
Journal | Journal of dental research
(J Dent Res)
Vol. 91
Issue 9
Pg. 847-52
(Sep 2012)
ISSN: 1544-0591 [Electronic] United States |
PMID | 22805294
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Cariostatic Agents
- Caseins
- casein phosphopeptide-amorphous calcium phosphate nanocomplex
- Fluorides
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Topics |
- Cariostatic Agents
(therapeutic use)
- Caseins
(therapeutic use)
- Child, Preschool
- DMF Index
- Dental Caries
(pathology, prevention & control)
- Dental Enamel
(pathology)
- Double-Blind Method
- Female
- Fluorides
(therapeutic use)
- Humans
- Logistic Models
- Male
- Thailand
- Tooth, Deciduous
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