Antioxidant composition causes antiexsudorific effect in the model of chronic venous insufficiency.

Abstract	Venous hypertension and swelling of the hind limbs was demonstrated to develop in rat model of chronic venous insufficiency. It was found that 14-day course of dihydroquercetin (50 mg/kg) and lipoic acid (50 mg/kg) administered intragastrically prevented the increase in hind limb volume and reduced the severity of edema of rat muscle tissue in chronic venous insufficiency.
Authors	I S Ivanov, A V Sidekhmenova, O I Aliev, T I Fomina, L A Ermolaeva, N A Tyukavkin, M B Plotnikov
Journal	Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 152 Issue 1 Pg. 25-7 (Nov 2011) ISSN: 1573-8221 [Electronic] United States
PMID	22803031 (Publication Type: Journal Article)
Chemical References	Antioxidants Thioctic Acid Quercetin taxifolin
Topics	Animals Antioxidants (pharmacology) Chronic Disease Edema (etiology, prevention & control) Hindlimb (blood supply, pathology) Male Muscle, Skeletal (blood supply, pathology) Quercetin (analogs & derivatives, pharmacology) Rats Rats, Wistar Statistics, Nonparametric Thioctic Acid (pharmacology) Venous Insufficiency (complications, drug therapy)

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