Effectiveness of 3-week intervention of Shi Quan Da Bu Tang for alleviating hematotoxicity among patients with breast carcinoma receiving chemotherapy.

Abstract

PURPOSE:

Although Shi Quan Da Bu Tang (SQDBT) has been used to treat cancer patients clinically, very few studies evaluating the effectiveness of SQDBT using objective indicators have been published. The study objectives were to examine the effectiveness of SQDBT for alleviating hematotoxicity, as indicated by white blood cell (WBC) counts and hemoglobin (Hb) levels, among patients with breast carcinoma receiving chemotherapy.

METHODS:

The authors identified patients with breast carcinoma who received chemotherapy in a teaching hospital in Taipei in 2008 through a chart review process. Only patients with initial WBC counts of <4000/µL were included. The case group was composed of 47 chemotherapy courses treated with SQDBT, whereas the comparison group included 257 courses without SQDBT. The complete blood count test was done before start of a chemotherapy course and 1 week after chemotherapeutic drugs were given.

RESULTS:

Age, cancer stage, cancer status, use of granulocyte colony-stimulating factor, and chemotherapy drugs were controlled in the model. Patients who took SQDBT had significantly increased WBC counts, especially neutrophils, and Hb after chemotherapy (adjusted β = 1202.51, 95% confidence interval [CI] 440.45-1964.57 for WBC; β = 834.83, 95% CI = 197.35-1472.31 for neutrophils; β = 0.34, 95% CI = 0.05-0.63 for Hb). There were no significant differences in tumor markers CEA and CA153 between patients given SQDBT or not after chemotherapy.

CONCLUSION:

SQDBT is effective in alleviating hematotoxicity among patients with breast carcinoma receiving chemotherapy, without affecting the presentation of tumor markers in the short term. More study is needed to determine long-term outcomes such as recurrence and survival.

• Authors: Sheng-Miauh Huang, Li-Yin Chien, Cheng-Jeng Tai, Jeng-Fong Chiou, Ching-Shyang Chen, Chen-Jei Tai
• Journal: Integrative cancer therapies (Integr Cancer Ther) Vol. 12 Issue 2 Pg. 136-44 (Mar 2013) ISSN: 1552-695X [Electronic] United States
• PMID: 22801942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Drugs, Chinese Herbal
• Hemoglobins
• juzentaihoto

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (blood, drug therapy)
• Carcinoma (blood, drug therapy)
• Case-Control Studies
• Chemical and Drug Induced Liver Injury (blood, drug therapy, etiology)
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Female
• Hemoglobins (metabolism)
• Humans
• Leukocyte Count
• Leukocytes (drug effects)
• Middle Aged