Effect of micronutrient sprinkles on reducing anemia: a cluster-randomized effectiveness trial.

To evaluate the effectiveness of Sprinkles alongside infant and young child feeding (IYCF) education compared with IYCF education alone on anemia, deficiencies in iron, vitamin A, and zinc, and growth in Cambodian infants.
Cluster-randomized effectiveness study.
Cambodian rural health district.
Among 3112 infants aged 6 months, a random subsample (n = 1350) was surveyed at baseline and 6-month intervals to age 24 months.
Daily micronutrient Sprinkles alongside IYCF education vs IYCF education alone for 6 months from ages 6 to 11 months.
Prevalence of anemia; iron, vitamin A, and zinc deficiencies; and growth via biomarkers and anthropometry.
Anemia prevalence (hemoglobin level <11.0 g/dL [to convert to grams per liter, multiply by 10.0]) was reduced in the intervention arm compared with the control arm by 20.6% at 12 months (95% CI, 9.4-30.2; P = .001), and the prevalence of moderate anemia (hemoglobin level <10.0 g/dL) was reduced by 27.1% (95% CI, 21.0-31.8; P < .001). At 12 and 18 months, iron deficiency prevalence was reduced by 23.5% (95% CI, 15.6-29.1; P < .001) and 11.6% (95% CI, 2.6-17.9; P = .02), respectively. The mean serum zinc concentration was increased at 12 months (2.88 μg/dL [to convert to micromoles per liter, multiply by 0.153]; 95% CI, 0.26-5.42; P = .03). There was no statistically significant difference in the prevalence of zinc and vitamin A deficiencies or in growth at any time.
Sprinkles reduced anemia and iron deficiency and increased the mean serum zinc concentration in Cambodian infants. Anemia and zinc effects did not persist beyond the intervention period. TRIAL REGISTRATION anzctr.org.au Identifier: ACTRN12608000069358.
AuthorsSusan J Jack, Kevanna Ou, Mary Chea, Lan Chhin, Robyn Devenish, Mary Dunbar, Chanthol Eang, Kroeun Hou, Sokhoing Ly, Mengkheang Khin, Sophanneary Prak, Ratana Reach, Aminuzzaman Talukder, La-Ong Tokmoh, Sophia Leon de la Barra, Philip C Hill, Peter Herbison, Rosalind S Gibson
JournalArchives of pediatrics & adolescent medicine (Arch Pediatr Adolesc Med) Vol. 166 Issue 9 Pg. 842-50 (Sep 2012) ISSN: 1538-3628 [Electronic] United States
PMID22801933 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Hemoglobins
  • Micronutrients
  • Retinol-Binding Proteins
  • Ferritins
  • Iron
  • Zinc
  • Anemia, Iron-Deficiency (blood, prevention & control)
  • Anthropometry
  • Cluster Analysis
  • Dietary Supplements
  • Ferritins (metabolism)
  • Growth Disorders (etiology)
  • Hemoglobins (metabolism)
  • Humans
  • Infant
  • Iron (deficiency)
  • Micronutrients (administration & dosage)
  • Retinol-Binding Proteins (metabolism)
  • Vitamin A Deficiency (blood, prevention & control)
  • Zinc (deficiency)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: