Abstract | OBJECTIVES: It is well known that a poorly differentiated endometrial adenocarcinoma shows more rapid progression and a worse response to therapy than a well-differentiated endometrial adenocarcinoma. Qualitative and quantitative changes of cell surface glycolipids occur during neoplastic transformation. Sulfatide is one of the sulfated glycolipids in the cell membrane that may have an important role in various functions such as cell adhesion. To examine the molecular background of the morphological and biological features of well-differentiated and poorly differentiated cancer, we measured the levels of lipids, especially glycolipids, in tumor tissues from patients with endometrial carcinoma. MATERIALS AND METHODS: RESULTS: CONCLUSION: These findings suggest that sulfatide contributes to the well-differentiated phenotype of endometrial adenocarcinoma and that it is being expressed in normal uterine endometrium at sites of gland formation during the luteal phase, as we have previously reported.
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Authors | Taro Sugiyama, Masaki Miyazawa, Mikio Mikami, Yumiko Goto, Yoshihiro Nishijima, Masae Ikeda, Takeshi Hirasawa, Toshinari Muramatsu, Susumu Takekoshi, Masao Iwamori |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 22
Issue 7
Pg. 1192-7
(Sep 2012)
ISSN: 1525-1438 [Electronic] England |
PMID | 22801032
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Sulfoglycosphingolipids
- Sulfotransferases
- galactosylceramide sulfotransferase
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Cell Differentiation
- Chromatography, Thin Layer
- Endometrial Neoplasms
(metabolism, pathology)
- Female
- Humans
- Immunoenzyme Techniques
- Neoplasm Grading
- Prognosis
- RNA, Messenger
(genetics)
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Sulfoglycosphingolipids
(metabolism)
- Sulfotransferases
(genetics, metabolism)
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