Liver fibrosis and five year survival of hepatocellular cancer cases undergoing transcatheter arterial chemo embolization using small doses.

Abstract

OBJECTIVE:

To investigate liver fibrosis, TGF-?1 levels and curative effects on hepatocellular carcinoma (HCC) with small and conventional dose perfusion chemotherapy by transcatheter arterial chemo embolization (TACE).

METHODS:

Thirty-six hepatocellular carcinoma patients not indicated for surgical resection underwent super- selective transcatheter arterial chemoembolization, divided into small dose (n=15) and conventional dose (n=21) chemotherapy groups.

RESULTS:

With conventional doses, four indices of liver fibrosis focusing on hyaluronate acide (HA), human procollagen type-III (hPC-III), collagen type-IV (IV-C) and transforming growth factor-βl (TGF-β1) were obviously increased postoperative compared with preoperative (P<0.01); in contrast, with small doses there were no significant differences except for TGF-β1. Five year survival demonstrated no significant differences between the two groups (P>0.05).

CONCLUSION:

To hepatocellular carcinoma patients treated by TACE, reducing doses of chemotherapy drugs can reduce progress of liver fibrosis, without impacting on five year survival.

• Authors: Hong Li, Yaohong Hu, Na Li, Yan Zhou
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 4 Pg. 1589-93 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22799372 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type III
• Collagen Type IV
• Laminin
• Transforming Growth Factor beta1
• Epirubicin
• Mitomycin
• Iodized Oil
• Hyaluronic Acid
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Carcinoma, Hepatocellular (therapy)
• Chemoembolization, Therapeutic (adverse effects)
• Chi-Square Distribution
• Collagen Type III (blood)
• Collagen Type IV (blood)
• Epirubicin (administration & dosage)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Hyaluronic Acid (blood)
• Iodized Oil (administration & dosage)
• Kaplan-Meier Estimate
• Laminin (blood)
• Liver Cirrhosis (blood, chemically induced, prevention & control)
• Liver Neoplasms (therapy)
• Male
• Mitomycin (administration & dosage)
• Transforming Growth Factor beta1 (blood)
• Treatment Outcome