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Surface-modified protein nanospheres as potential antiviral agents.

Abstract
A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.
AuthorsDana Baram-Pinto, Sourabh Shukla, Michal Richman, Aharon Gedanken, Shai Rahimipour, Ronit Sarid
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 48 Issue 67 Pg. 8359-61 (Aug 28 2012) ISSN: 1364-548X [Electronic] England
PMID22798998 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Sulfonic Acids
  • Serum Albumin, Bovine
  • Mercaptoethanol
Topics
  • Animals
  • Antiviral Agents (chemistry, pharmacology)
  • Cattle
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Herpesvirus 1, Human (drug effects)
  • Mercaptoethanol (chemistry)
  • Nanospheres (chemistry)
  • Serum Albumin, Bovine (chemistry)
  • Sulfonic Acids (chemistry)
  • Surface Properties

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