The aim of this study was to investigate the influence of
rice bran oil consumption on plasma
lipids and
insulin resistance in patients with
type 2 diabetes. Thirty-five patients with
type 2 diabetes were randomly assigned to a placebo group or a
rice bran oil group. The placebo group consumed 250 mL
soybean oil-modified milk (18 g
soybean oil) daily for 5 weeks, and the
rice bran oil group consumed 250 mL
rice bran oil modified milk (18 g
rice bran oil) daily for 5 weeks. At week 0 and week 5, anthropometric measurements, hematology tests, and an oral-
glucose-tolerance test were conducted. The results showed that the homeostasis model assessment index of
insulin resistance, the area under the curve for postprandial serum
insulin, and serum
low-density-lipoprotein cholesterol concentrations increased significantly in the placebo group. In the
rice bran oil group, fasting and 2-h postprandial
blood glucose concentrations and the area under the curve for postprandial plasma
glucose increased significantly; however, total serum
cholesterol and
low-density-lipoprotein cholesterol concentrations decreased significantly. However, the homeostasis model assessment index of
insulin resistance was not significantly different. Consumption of 18 g
rice bran oil modified milk daily for 5 weeks significantly decreased total serum
cholesterol concentrations and tended to decrease
low-density-lipoprotein cholesterol concentrations in patients with
type 2 diabetes. However, no significant influence on
insulin resistance was observed.