Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine.

Abstract

PURPOSE:

To explore surface-immobilized and suspended modalities of the hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI) for the ability to reduce viral infectivity in aqueous solutions containing herpes simplex viruses (HSVs) 1 and 2.

METHODS:

Surface-immobilized (coated onto surfaces) and suspended DMPEI were incubated with aqueous solutions containing HSV-1 or -2 to measure the antiviral effect of the hydrophobic polycation's formulations on HSVs.

RESULTS:

DMPEI coated on either polyethylene slides or male latex condoms dramatically decreases infectivity in solutions containing HSV-1 or -2. Moreover, DMPEI suspended in aqueous solution markedly reduces the infectious titer of these HSVs.

CONCLUSION:

Our results suggest potential uses of DMPEI for both prophylaxis (in the form of coated condoms) and treatment (as a topical suspension) for HSV infections.

• Authors: Alyssa M Larson, Hyung Suk Oh, David M Knipe, Alexander M Klibanov
• Journal: Pharmaceutical research (Pharm Res) Vol. 30 Issue 1 Pg. 25-31 (Jan 2013) ISSN: 1573-904X [Electronic] United States
• PMID: 22798261 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antiviral Agents
• N,N-dodecyl,methyl-polyethylenimine
• Polyethyleneimine

Topics

• Antiviral Agents (administration & dosage, therapeutic use)
• Condoms (virology)
• Herpes Genitalis (prevention & control, transmission, virology)
• Herpes Simplex (prevention & control, transmission, virology)
• Herpesvirus 1, Human (drug effects, pathogenicity)
• Herpesvirus 2, Human (drug effects, pathogenicity)
• Humans
• Male
• Polyethyleneimine (administration & dosage, analogs & derivatives, therapeutic use)
• Surface Properties