[Cigarette smoking and group I pepsinogen levels. Study in a normal population].

Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.
AuthorsB Germanà, F Di Mario, F Vianello, P Dotto, D Faggian, M Plebani, A Saggioro, R Naccarato
JournalGiornale di clinica medica (G Clin Med) 1990 Aug-Sep Vol. 71 Issue 8-9 Pg. 493-5 ISSN: 0017-0275 [Print] ITALY
Vernacular TitleFumo di sigaretta e livelli di pepsinogeno del gruppo Io. Studio in una popolazione normale.
PMID2279624 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Pepsinogens
  • Peptide Fragments
  • pepsinogen (1-12)
  • Pepsinogen A
  • Adult
  • Aged
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Pepsinogen A
  • Pepsinogens (blood)
  • Peptic Ulcer (blood, etiology)
  • Peptide Fragments (blood)
  • Radioimmunoassay
  • Risk Factors
  • Sampling Studies
  • Smoking (blood)

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