Abstract | OBJECTIVE: METHODS:
Ventricular fibrillation was induced in 20 healthy Landrace/Large White piglets, which were subsequently left untreated for 8 minutes. Ten animals were randomly assigned into the control group and were resuscitated according to the 2005 European Resuscitation Council guidelines, and 10 piglets were assigned into the passive leg raising group and were resuscitated with the legs passively raised at 45° with the aid of a special purpose-made metallic device. End points were either return of spontaneous circulation or asystole. RESULTS: Return of spontaneous circulation was observed in 6 and 9 animals from the control and the passive leg raising group, respectively (P = .121; odds ratio = 0.16; 95% confidence interval, 0.01-1.87). Just prior to the first defibrillation attempt, coronary perfusion pressure was significantly higher in the passive leg raising group (22.8 ± 9.5 vs 10.6 ± 6.5 mm Hg, P < .004); but no subsequent significant differences were observed. Although all animals that restored spontaneous circulation survived for 24 hours, neurologic alertness score was significantly better in the animals treated with passive leg raising (90 ± 10 vs 76.6 ± 12.1, P = .037). CONCLUSIONS: Passive leg raising during cardiopulmonary resuscitation significantly increased coronary perfusion pressure in the minute prior to the first shock. Return of spontaneous circulation and 24-hour survival rate were comparable between groups. However, the animals in the passive leg raising group exhibited significantly higher neurological scores.
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Authors | Vasileios Dragoumanos, Nicoletta Iacovidou, Athanasios Chalkias, Pavlos Lelovas, Anastasios Koutsovasilis, Apostolos Papalois, Theodoros Xanthos |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 30
Issue 9
Pg. 1935-42
(Nov 2012)
ISSN: 1532-8171 [Electronic] United States |
PMID | 22795422
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Topics |
- Animals
- Blood Pressure
- Cardiopulmonary Resuscitation
(methods)
- Disease Models, Animal
- Extremities
- Heart Rate
- Hypoxia, Brain
(etiology, prevention & control)
- Male
- Patient Positioning
- Swine
- Treatment Outcome
- Ventricular Fibrillation
(complications, therapy)
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