Abstract | INTRODUCTION: The cystic fibrosis (CF) airway mucus is an ideal niche in which many bacteria can develop antibiotic- and phagocyte-resistance in unique structures known as "mode II biofilms" where bacteria are embedded within the mucus, yet unattached to airway epithelial cells. Pseudomonas aeruginosa is the dominant CF pathogen, yet herein the authors provide burgeoning evidence that obligate anaerobic bacteria (e.g., Prevotella) actually thrive within the CF mucus, a paradigmatic shift that chronic CF is an "aerobic" disease. Interestingly, CF organisms repress virulence factor production (e.g., P. aeruginosa) while others (e.g., S. aureus) increase them under anaerobic conditions. AREAS COVERED: The authors shed additional light on (i) the anoxic nature of the CF airway mucus, (ii) the relative commonality of anaerobic bacteria isolated from CF sputum, (iii) virulence factor production and cross-talk between obligate anaerobes and P. aeruginosa relative to disease progression/remission, (iv) the role of mucoidy in CF, and (v) the role of nitrosative stress in activation of bacteriophage and pyocins within biofilms. EXPERT OPINION: The authors conclude with insight as to how we might treat some CF bacteria during mode II biofilm infections that utilizes a metabolite of bacterial anaerobic respiration and an aerobic oxidation product of airway-generated NO, acidified NO(2)(-).
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Authors | Shengchang Su, Daniel J Hassett |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 16
Issue 9
Pg. 859-73
(Sep 2012)
ISSN: 1744-7631 [Electronic] England |
PMID | 22793158
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Biofilms
(growth & development)
- Cystic Fibrosis
(complications)
- Humans
- Mucus
(microbiology)
- Pseudomonas Infections
(complications, microbiology)
- Pseudomonas aeruginosa
(physiology)
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