[Flow cytometric analysis of peripheral nerve tumors].

Abstract

Flow cytometric DNA analysis was performed on formalin fixed paraffin-embedded samples taken from 43 cases of peripheral nerve tumors. Fourteen samples were taken from benign tumors, 11 from actively proliferative tumors and 12 from malignant tumors. Ploidy pattern and proliferative index of tumors were estimated. All samples of benign tumors showed a diploid model of DNA content whereas DNA aneuploidy was encountered in 75% (12/16) of the malignant tumors and 25% (4/16) of the actively proliferative tumors. The proliferative index (PI) of benign tumors (medium: 24.8%) was lower than that of proliferative tumors (medium: 42.7%). The proliferative index of malignant tumors was the highest in the experimental group (medium: 51.2%). These results were conformable to the malignant degree of histologic grading and prognosis.

• Authors: X Han
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 19 Issue 3 Pg. 200-3 (Sep 1990) ISSN: 0529-5807 [Print] China
• PMID: 2279313 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Aneuploidy
• Cell Division
• DNA, Neoplasm (analysis)
• Diploidy
• Flow Cytometry
• Humans
• Neurilemmoma (genetics, pathology)
• Neurofibroma (genetics, pathology)
• Peripheral Nervous System Neoplasms (genetics, pathology)