Synthesis, surface modification, characterization, and biomedical in vitro applications of organically modified silica (ORMOSIL) nanoparticles.

Abstract

Organically modified silica (ORMOSIL) nanoparticles, owing to the presence of lipophilic organic groups, can host active lipophilic molecules in their interior, as well as form electrostatic complex with therapeutic agents such as genes on their surface. Owing to this fact, they have numerous potential applications in diagnostic imaging, as well as drug, and gene delivery. Here we describe the synthesis, characterization, and biomedical applications of ORMOSIL nanoparticles encapsulated with either an anticancer drug (for cancer chemotherapy), or a photosensitizer drug (for photodynamic therapy), or complexed with a plasmid DNA (for gene therapy).

• Authors: Diksha, Indrajit Roy
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 906 Pg. 365-79 ( 2012) ISSN: 1940-6029 [Electronic] United States
• PMID: 22791449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Emulsions
• Photosensitizing Agents
• Silicon Dioxide
• Doxorubicin

Topics

• Cell Line, Tumor
• Cell Survival
• Doxorubicin (administration & dosage)
• Drug Delivery Systems
• Emulsions (chemistry)
• Gene Transfer Techniques
• Humans
• Nanoparticles (chemistry)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage)
• Plasmids
• Silicon Dioxide (chemistry)
• Transfection