Improvement of a compressed inferior vena cava due to IgG4-related retroperitoneal fibrosis with steroid therapy.

Abstract

A 79-year-old man had a 3.5-year history of edema of the lower extremities of unknown etiology. Abdominal computed tomography showed a soft tissue mass around the abdominal aorta, and the biopsy revealed dense fibrosis with abundant infiltration of IgG4-positive plasma cells. His serum IgG4 level was increased to 188 mg/dL. His lower extremity edema was induced by stenosis of the inferior vena cava (IVC) due to the mass. With a diagnosis of IgG4-related retroperitoneal fibrosis, he was treated with steroid, and the leg edema decreased with improvement of patency of the IVC and reduction of the soft tissue mass.

• Authors: Mizuki Nishimura, Terumi Kamisawa, Yasuyuki Kitahara, Akihiro Nishizawa, Taku Tabata, Seiichi Hara, Sawako Kuruma, Kazuro Chiba, Takashi Fujiwara, Go Kuwata, Hideto Egashira, Koichi Koizumi, Junko Fujiwara, Takeo Arakawa, Kumiko Momma
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 13 Pg. 1705-7 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 22790130 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin G
• Prednisolone

Topics

• Aged
• Constriction, Pathologic
• Humans
• Immunoglobulin G (blood)
• Magnetic Resonance Angiography
• Male
• Prednisolone (therapeutic use)
• Retroperitoneal Fibrosis (drug therapy, immunology, pathology)
• Tomography, X-Ray Computed
• Vena Cava, Inferior (pathology)