Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.
Abstract | PURPOSE: Various immune mediators are hypothesized to have important roles in the pathogenesis of vitreoretinal B-cell lymphoma, although the exact mechanisms remain unclear. We determined the immune mediator profile in the vitreous of eyes with vitreoretinal B-cell lymphoma. METHODS: RESULTS: Vitreous levels of BCA-1, bFGF, Fas ligand, granzyme A, granzyme B, IFN-γ, IL-6, IL-8, IL-10, IP-10, MCP-1, Mig, MIP-1α, MIP-1β, OSM, RANTES, and SDF-1α were significantly higher in vitreoretinal B-cell lymphoma patients than in controls. A moderate-to-strong positive correlation was observed between granzyme A and BCA-1, IFN-γ, or MIP-1β; between IFN-γ and Mig or SDF-1α; between IL-6 and IL-8, IL-10, IP-10, or MCP-1; between IL-8 and MCP-1, Mig, or MIP-1β; between IL-10 and MCP-1 or MIP-1α; between Mig and IP-10 or Mig; and between MIP-1α and MIP-1β. CONCLUSIONS: Our study suggested that elevated vitreous levels of various immune mediators inducing growth, migration, and apoptosis of B-cell lymphoma are involved possibly in the pathophysiology of vitreoretinal B-cell lymphoma.
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Authors | Yoshihiko Usui, Yoshihiro Wakabayashi, Yoko Okunuki, Keisuke Kimura, Kazuki Tajima, Ryusaku Matsuda, Shunichiro Ueda, Juan Ma, Takeshi Nagai, Hideki Mori, Takeshi Kezuka, Toshitaka Nagao, Hiroshi Goto |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 53
Issue 9
Pg. 5395-402
(Aug 09 2012)
ISSN: 1552-5783 [Electronic] United States |
PMID | 22789925
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Case-Control Studies
- Cytokines
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Female
- Granzymes
(metabolism)
- Humans
- Lymphoma, B-Cell
(metabolism)
- Male
- Retinal Neoplasms
(metabolism)
- Vitreous Body
(metabolism, pathology)
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