Abstract | BACKGROUND: METHODS AND RESULTS: In this institutional review board-approved study, we retrospectively reviewed the electronic medical records of all patients (N=91) who had videoscopic LCSD at our institution from 2005 to 2011. Data were analyzed for the subset (n=27) who were denervated for an underlying diagnosis other than autosomal dominant or sporadic long-QT syndrome. The spectrum of arrhythmogenic disease included catecholaminergic polymorphic ventricular tachycardia (n=13), Jervell and Lange-Nielsen syndrome (n=5), idiopathic ventricular fibrillation (n=4), left ventricular noncompaction (n=2), hypertrophic cardiomyopathy (n=1), ischemic cardiomyopathy (n=1), and arrhythmogenic right ventricular cardiomyopathy (n=1). Five patients had LCSD because of high-risk assessment and β-blocker intolerance, none of whom had a sentinel breakthrough cardiac event at early follow-up. Among the remaining 22 previously symptomatic patients who had LCSD as secondary prevention, all had an attenuation in cardiac events, with 18 having no breakthrough cardiac events so far and 4 having experienced ≥1 post-LCSD breakthrough cardiac event. CONCLUSIONS: LCSD may represent a substrate-independent antifibrillatory treatment option for patients with life-threatening ventricular arrhythmia syndromes other than long-QT syndrome. The early follow-up seems promising, with a marked reduction in the frequency of cardiac events postdenervation.
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Authors | Mira A Coleman, J Martijn Bos, Jonathan N Johnson, Heidi J Owen, Claude Deschamps, Christopher Moir, Michael J Ackerman |
Journal | Circulation. Arrhythmia and electrophysiology
(Circ Arrhythm Electrophysiol)
Vol. 5
Issue 4
Pg. 782-8
(Aug 01 2012)
ISSN: 1941-3084 [Electronic] United States |
PMID | 22787014
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Adolescent
- Adult
- Arrhythmogenic Right Ventricular Dysplasia
(physiopathology, surgery)
- Child
- Child, Preschool
- Disease-Free Survival
- Endoscopy
(adverse effects)
- Female
- Heart
(innervation)
- Humans
- Infant
- Isolated Noncompaction of the Ventricular Myocardium
(physiopathology, surgery)
- Jervell-Lange Nielsen Syndrome
(physiopathology, surgery)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Minnesota
- Recurrence
- Retrospective Studies
- Sympathectomy
(adverse effects, methods)
- Sympathetic Nervous System
(physiopathology)
- Tachycardia, Ventricular
(diagnosis, physiopathology, surgery)
- Time Factors
- Treatment Outcome
- Ventricular Fibrillation
(diagnosis, physiopathology, surgery)
- Video-Assisted Surgery
(adverse effects)
- Young Adult
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