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Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases.

AbstractBACKGROUND:
Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). The results of longer-term continuous treatment are lacking.
OBJECTIVE:
To evaluate the long-term safety and efficacy of alitretinoin for the treatment of CHD.
METHODS:
The Physician's Global Assessment (PGA) and Modified Total Lesion Symptom Score (MTLSS) were used to assess CHD improvement in three patients treated with alitretinoin (10-30 mg/d). Patients had routine bloodwork and were monitored for adverse events.
RESULTS:
Significant improvement in MTLSS scores (≈ 76%) was seen at 2 months (p < .002) and maintained for the 3-year treatment period with occasional dosage adjustments. No significant adverse events developed that necessitated treatment withdrawal.
CONCLUSION:
Alitretinoin was well tolerated in the treatment of these three CHD patients who were carefully monitored over this prolonged treatment period.
AuthorsWayne P Gulliver, Kenneth A Baker
JournalJournal of cutaneous medicine and surgery (J Cutan Med Surg) 2012 Jul-Aug Vol. 16 Issue 4 Pg. 267-71 ISSN: 1203-4754 [Print] United States
PMID22784520 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Alitretinoin
  • Tretinoin
Topics
  • Administration, Oral
  • Aged
  • Alitretinoin
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Chronic Disease
  • Dermatitis (drug therapy)
  • Female
  • Hand Dermatoses (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Tretinoin (administration & dosage, therapeutic use)

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