Canakinumab in gout.

Abstract

INTRODUCTION:

Gout is a painful inflammatory arthritis with a prevalence of approximately 4% in the United States, affecting an estimated 8.3 million adults. The past 20 years have shown significant increases in the number of patients with gout and its incidence may still be increasing. Current treatment options to control the pain and inflammation of acute gout include nonsteroidal anti-inflammatory drugs, colchicine and corticosteroids, although patients are often unresponsive to, intolerant of, or have contraindications for, these therapies. Additional treatment options are therefore needed for this population with difficult-to-treat gout.

AREAS COVERED:

Currently available and investigational anti-inflammatory agents for acute and chronic gout will briefly be reviewed. Canakinumab , a fully human monoclonal anti-interleukin (IL)-1β antibody that selectively blocks IL-1β and that is being investigated for the treatment of gout, will be discussed in greater detail.

EXPERT OPINION:

Canakinumab has been found to be superior to triamcinolone acetonide in acute gout and to colchicine in gout attack prophylaxis in reducing pain and risk of new gout attacks. Canakinumab's long half-life contributes to its prolonged anti-inflammatory effects.

• Authors: Naomi Schlesinger
• Journal: Expert opinion on biological therapy (Expert Opin Biol Ther) Vol. 12 Issue 9 Pg. 1265-75 (Sep 2012) ISSN: 1744-7682 [Electronic] England
• PMID: 22784099 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Gout Suppressants
• Interleukin-1beta
• canakinumab

Topics

• Acute Disease
• Animals
• Anti-Inflammatory Agents (pharmacokinetics, therapeutic use)
• Antibodies, Monoclonal (pharmacokinetics, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Chronic Disease
• Gout (drug therapy, immunology, physiopathology)
• Gout Suppressants (pharmacokinetics, therapeutic use)
• Half-Life
• Humans
• Interleukin-1beta (antagonists & inhibitors, metabolism)
• Treatment Outcome