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Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study.

AbstractOBJECTIVE:
Post-infective irritable bowel syndrome (PI-IBS) is characterized by continuing symptoms of irritable bowel syndrome, typically diarrhea-predominant, following an episode of acute gastroenteritis. There is often an increase in sub-epithelial inflammatory and neuroendocrine cells on colonic mucosal biopsy. Mesalamine is an anti-inflammatory agent, effective in the treatment of inflammatory bowel disease. The goal of this study was to compare mesalamine to placebo on symptoms and quality-of-life (QOL) in PI-IBS.
MATERIAL AND METHODS:
Twenty patients who developed diarrhea-predominant IBS after gastroenteritis were randomized to receive mesalamine (Asacol®) 1.6 gm b.i.d. or placebo for 12 weeks in a double-blind placebo-controlled study. QOL was assessed using the IBS-QOL questionnaire. Stool frequency, stool consistency, urgency, severity of abdominal pain, severity of bloating, and global-improvement scale were recorded in daily diaries for 7 days at baseline and every 4 weeks. Data were analyzed by comparing the change from baseline to last follow-up.
RESULTS:
One patient withdrew after randomization; data were incomplete in two patients. Thus, data were analyzed from 17 patients (11 men and 6 women, median age: 27 years, range 22-45 years). Mesalamine was not associated with significant improvement in global symptoms, abdominal pain, bloating, stool urgency, frequency, or consistency (all p ≥ 0.11) or QOL (p ≥ 0.16).
CONCLUSIONS:
There was no significant improvement in global symptoms or overall QOL with mesalamine in patients with PI-IBS.
AuthorsAshok K Tuteja, John C Fang, Manal Al-Suqi, Gregory J Stoddard, Devon C Hale
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 47 Issue 10 Pg. 1159-64 (Oct 2012) ISSN: 1502-7708 [Electronic] England
PMID22783919 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Mesalamine
Topics
  • Abdominal Pain (etiology, physiopathology)
  • Acute Disease
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Biopsy
  • Diarrhea (etiology, physiopathology)
  • Double-Blind Method
  • Female
  • Gastroenteritis (complications)
  • Humans
  • Intestinal Mucosa (pathology)
  • Irritable Bowel Syndrome (drug therapy, etiology, pathology, physiopathology, psychology)
  • Male
  • Mesalamine (administration & dosage)
  • Pain Measurement
  • Pilot Projects
  • Quality of Life
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome

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