Reconstruction of full-thickness defects with bovine-derived collagen/elastin matrix: a series of challenging cases and the first reported post-burn facial reconstruction.

Abstract

Reconstruction of full-thickness defects may benefit from integration of dermal substitutes, which serve as a foundation for split-thickness skin grafts, thus enhancing short and long-term results. We present a series of 7 patients who were treated between 2010 and 2012 for complicated full-thickness defects by the second-generation collagen/elastin matrix Matriderm® covered by a split-thickness skin graft. The defects resulted from malignancy resection, trauma, and post-burn scar reconstruction. Overall graft take was excellent and no complications were noted regarding the dermal substitute. Graft quality was close to normal skin in terms of elasticity, pliability, texture, and color. Good contour and cushioning of defects in weight bearing areas was also achieved. Matriderm was found to be a useful adjunct to full-thickness defect reconstruction, especially in difficult areas where the desired result is a scar of the highest quality possible.

• Authors: Josef Haik, Oren Weissman, Gabriel Hundeshagen, Nimrod Farber, Moti Harats, Shira M Rozenblatt, Lars Peter Kamolz, Eyal Winkler, Isaac Zilinsky
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 11 Issue 7 Pg. 866-8 (Jul 2012) ISSN: 1545-9616 [Print] United States
• PMID: 22777231 (Publication Type: Case Reports, Journal Article)

Chemical References

• Collagen
• Elastin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Animals
• Burns (pathology, surgery)
• Cattle
• Cicatrix (etiology)
• Collagen (administration & dosage)
• Elasticity
• Elastin (administration & dosage)
• Face
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasms (pathology, surgery)
• Plastic Surgery Procedures (methods)
• Skin Transplantation (methods)
• Skin, Artificial
• Treatment Outcome
• Wounds and Injuries (pathology, surgery)
• Young Adult