Hypothermia, hypotension, hypersomnia, and obesity associated with hypothalamic lesions in a patient positive for the anti-aquaporin 4 antibody: a case report and literature review.

To describe a patient positive for the anti-aquaporin 4 antibody with hypothalamic lesions showing hypothermia, hypotension, hypersomnia, and obesity.
Case report.
University hospital.
We describe a 21-year-old woman who was positive for anti-aquaporin 4 antibody and presented with hypothermia, hypotension, and hypersomnia owing to bilateral hypothalamic lesions as the only abnormal clinical finding.
Immediate steroid administration resulted in significant improvement of the patient's vital signs and imaging findings; however, her cognitive impairment and sleepiness persisted, and she subsequently developed obesity. Decreased cerebrospinal fluid orexin levels and sleep studies confirmed the diagnosis of narcolepsy due to medical condition. Physicians should be aware that neuromyelitis optica spectrum disorders can initially involve the hypothalamus.
We emphasize that measurement of anti-aquaporin 4 antibody is of clinical importance in the differential diagnosis of hypothalamic lesions.
AuthorsKeisuke Suzuki, Toshiki Nakamura, Kenichi Hashimoto, Masayuki Miyamoto, Tomoko Komagamine, Takahide Nagashima, Naoki Izawa, Takashi Kanbayashi, Toshiyuki Takahashi, Koichi Hirata
JournalArchives of neurology (Arch Neurol) Vol. 69 Issue 10 Pg. 1355-9 (Oct 2012) ISSN: 1538-3687 [Electronic] United States
PMID22777080 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antibodies, Anti-Idiotypic
  • Aquaporin 4
  • Antibodies, Anti-Idiotypic (blood)
  • Aquaporin 4 (immunology)
  • Disorders of Excessive Somnolence (blood, complications, pathology)
  • Female
  • Humans
  • Hypotension (blood, complications, pathology)
  • Hypothalamus (pathology)
  • Hypothermia (blood, complications, pathology)
  • Magnetic Resonance Imaging
  • Obesity (blood, complications, pathology)
  • Young Adult

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