Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.

Abstract

INTRODUCTION:

NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2), involved in detoxification of environmental carcinogens and activation of chemotherapeutic agents, are supposed to play critical role in carcinogenesis. So, we aimed to investigate the association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer (EC) in north Indian population. We also performed Meta analysis of published literatures on NQO1 609C>T polymorphism to systematically evaluate its association with EC.

METHODS:

We genotyped NQO1 609C>T and NQO2 -3423G>A polymorphisms in 200 incident EC cases (including 150 follow-up cases) and 200 controls using PCR RFLP based methods. Binary logistic regression was applied for risk estimation, while Kaplan Meier and Cox regression tests were applied for survival analysis. All Meta analysis tests were performed using MIX 2.0 software.

RESULTS:

The present study did not find any significant association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC or its clinical phenotypes (histopathology, tumor location or lymph node metastasis) or interactions with lifestyle risk factors (tobacco usage, smoking, alcohol habit and occupational exposures). Meta analysis of NQO1 polymorphism also indicated null association of the polymorphism with EC overall or with cancer cases stratified by tumor histopathology/ethnicity. Moreover, no prognostic implication of both polymorphisms was observed in EC.

CONCLUSION:

NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population and results of Meta-analysis further reinforces null association of NQO1 609C>T polymorphism with EC susceptibility.

• Authors: Meenakshi Umar, Rohit Upadhyay, Shaleen Kumar, Uday Chand Ghoshal, Balraj Mittal
• Journal: Cancer epidemiology (Cancer Epidemiol) Vol. 36 Issue 6 Pg. e373-9 (Dec 2012) ISSN: 1877-783X [Electronic] Netherlands
• PMID: 22770696 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• NAD(P)H Dehydrogenase (Quinone)
• NQO1 protein, human
• NRH - quinone oxidoreductase2
• Quinone Reductases

Topics

• Adult
• Aged
• Aged, 80 and over
• Case-Control Studies
• Esophageal Neoplasms (enzymology, genetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• India
• Middle Aged
• NAD(P)H Dehydrogenase (Quinone) (genetics)
• Polymorphism, Single Nucleotide
• Prognosis
• Quinone Reductases (genetics)
• Risk Factors
• Survival Analysis