Abstract | BACKGROUND/PURPOSE: MATERIALS AND METHODS: This was a randomized, open-label, active-controlled parallel study on patients with postsurgical pain. Sixty patients who sustained moderate postsurgical pain (visual analog scale(3)3 cm) after undergoing implantation of venous access were randomized to two groups to receive either Ultracetor Depain-X for postoperative analgesia. Assessment items included pain intensity and pain relief ratings at the first 4 hours, and adverse events. RESULTS: There were initially 107 patients who were enrolled in this trial, but up to 45 (42.1%) of them were withdrawn during the study. In these 62 patients who complied with treatment ( Ultracet: Depain-X = 29: 33), pain relief scale indicated that Ultracet could provide a better analgesic effect than Depain-X provided at 1 hour (p < 0.05). At 4 hours, the pain score in the Ultracet group was significantly lower than that in the Depain-X group (p < 0.05). Adverse events, such as drowsiness, dizziness, and skin itching did not differ in both groups. CONCLUSION: Among patients with mild to moderate postoperative wound pain, single-dose Ultracet can provide slightly better analgesic efficacy than Depain-X in terms of onset and duration. Depain-X is no longer marketed in Europe, America, Taiwan and other countries, therefore, Ultracet can serve as a good substitute for treating postoperative pain.
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Authors | Feng-Sheng Lin, Wen-Ying Lin, Chia-Hsin Lai, Chien-Yu Chen, Chih-Peng Lin, Tzu-Fu Lin, Wei-Zen Sun |
Journal | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists
(Acta Anaesthesiol Taiwan)
Vol. 50
Issue 2
Pg. 49-53
(Jun 2012)
ISSN: 1875-452X [Electronic] China (Republic : 1949- ) |
PMID | 22769857
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012. Published by Elsevier B.V. |
Chemical References |
- Analgesics
- Drug Combinations
- Acetaminophen
- acetaminophen, dextropropoxyphene, drug combination
- Tramadol
- Dextropropoxyphene
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Topics |
- Acetaminophen
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Aged
- Analgesics
(therapeutic use)
- Dextropropoxyphene
(adverse effects, therapeutic use)
- Drug Combinations
- Female
- Humans
- Male
- Middle Aged
- Pain, Postoperative
(drug therapy)
- Tramadol
(administration & dosage, adverse effects)
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