Treatment of atrial fibrillation in horses by intravenous administration of quinidine.

Abstract

Intravenous administration of quinidine gluconate converted atrial fibrillation (AF) to sinus rhythm in 9 of 12 horses. Twelve horses that were diagnosed by ECG to have AF were administered up to 11 mg of quinidine gluconate/kg of body weight in 1.0- to 1.5-mg/kg bolus injections every 10 to 15 minutes. The total dose of quinidine administered IV ranged from 1.8 to 5.8 g. Increased ventricular rate, apprehension, and mild depression were observed during treatment. Other signs of toxicosis were not observed. One horse was successfully treated with IV administered quinidine gluconate on 3 occasions. Intravenous administration of quinidine is a safe and effective alternative for treatment of AF in some horses.

• Authors: W W Muir 3rd, S M Reed, S M McGuirk
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 197 Issue 12 Pg. 1607-10 (Dec 15 1990) ISSN: 0003-1488 [Print] United States
• PMID: 2276956 (Publication Type: Journal Article)

Chemical References

• Quinidine

Topics

• Animals
• Atrial Fibrillation (drug therapy, veterinary)
• Electrocardiography (veterinary)
• Female
• Horse Diseases (drug therapy)
• Horses
• Infusions, Intravenous (veterinary)
• Male
• Quinidine (administration & dosage, therapeutic use)