Assist devices: machine preservation of extended criteria donors.

Abstract

KEY POINTS:

1. Hypothermic machine perfusion (HMP) is in its infancy in clinical liver transplantation. Potential benefits include diminished preservation injury (PI) and improved graft function. 2. We have employed HMP in 21 extended criteria donor (ECD livers) at our center with excellent clinical outcomes. 3. Our experience with liver HMP is the only reported clinical experience worldwide representing a total of 41 successful liver transplant cases showing improved outcomes and diminished markers of ischemia/reperfusion injury. 4. Further multicenter and large scale trials are now warranted to further explore the benefits and applicability of liver HMP into the clinical mainstream.

• Authors: James V Guarrera
• Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (Liver Transpl) Vol. 18 Suppl 2 Pg. S31-3 (Nov 2012) ISSN: 1527-6473 [Electronic] United States
• PMID: 22767437 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 American Association for the Study of Liver Diseases.

Topics

• Cryopreservation
• Equipment and Supplies
• Humans
• Hypothermia, Induced (instrumentation, methods)
• Liver (blood supply)
• Liver Transplantation
• Reperfusion Injury (prevention & control)
• Tissue and Organ Procurement (methods)