Abstract | PURPOSE OF REVIEW:
Immediate hypersensitivity reactions are an important cause for mortality and morbidity in anesthesia. The present review considers reports covering epidemiology, diagnosis, and treatment of these reactions. RECENT FINDINGS: SUMMARY:
Hypersensitivity reactions remain a major cause of concern in the perioperative setting. Although largely under-reported, their incidence is higher than previously reported. NMBAs remain the most frequently incriminated drug, followed by latex and antibiotics. The number of reactions involving new allergens like vital dyes or nonsteroidal anti-inflammatory drugs is rapidly increasing. The mechanism of sensitization to NMBAs could be influenced by as yet unidentified environmental factors. The possible role of pholcodine is under investigation. Several guidelines concerning the diagnosis and management of immediate hypersensitivity reactions in anesthesia are now available.
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Authors | Paul M Mertes, Pascal Demoly, Jean M Malinovsky |
Journal | Current opinion in allergy and clinical immunology
(Curr Opin Allergy Clin Immunol)
Vol. 12
Issue 4
Pg. 361-8
(Aug 2012)
ISSN: 1473-6322 [Electronic] United States |
PMID | 22766618
(Publication Type: Journal Article, Review)
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Chemical References |
- Analgesics
- Anesthetics
- Morpholines
- Neuromuscular Blocking Agents
- Vasoconstrictor Agents
- Vasopressins
- pholcodine
- Codeine
- Epinephrine
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Topics |
- Adult
- Analgesics
(adverse effects)
- Anesthesia
(adverse effects)
- Anesthetics
(adverse effects)
- Codeine
(adverse effects, analogs & derivatives)
- Drug Hypersensitivity
(diagnosis, epidemiology, etiology, metabolism)
- Epinephrine
(adverse effects)
- Female
- Humans
- Male
- Morpholines
(adverse effects)
- Neuromuscular Blocking Agents
(adverse effects)
- Risk Factors
- Sex Factors
- Skin Tests
(methods)
- Vasoconstrictor Agents
(adverse effects)
- Vasopressins
(adverse effects)
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