Abstract |
To evaluate the association between vascular endothelial growth factor ( VEGF) gene polymorphisms and the risk of recurrent spontaneous abortion (RSA), a meta-analysis of published case-control studies for the VEGF gene polymorphisms (gene polymorphisms reported more than three times were selected) and the risk of RSA. Odds ratios ( ORs) and 95% confidence intervals (CIs) for codominant, dominant and recessive genetic models were assessed by RevMan software. Eight studies with 2813 cases and 2830 controls were included in this meta-analysis. The pooled analysis showed that -2578C/A, -1154G/A polymorphisms of VEGF were not significantly associated with the risk of RSA neither under codominant model nor under dominant model, nor under recessive model. Whereas, for -634G/C polymorphism, the pooled OR and 95% CI were 1.23 (1.01-1.49) under recessive model; and for 936C/T polymorphism, the pooled OR and 95% CI were 1.34 (1.07-1.67) and 1.40 (1.09-1.80) under codominant and dominant models, respectively. This meta-analysis suggested that VEGF gene -2578C/A, -1154G/A polymorphisms were not significantly associated with the risk of RSA, whereas, -634G/C and +936C/T polymorphisms were associated with the risk of RSA under specific genetic models.
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Authors | Bingzhen Zhang, Bingqin Dai, Xingliang Zhang, Zhiping Wang |
Journal | Gene
(Gene)
Vol. 507
Issue 1
Pg. 1-8
(Oct 01 2012)
ISSN: 1879-0038 [Electronic] Netherlands |
PMID | 22766401
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Abortion, Habitual
(genetics)
- Abortion, Spontaneous
(genetics)
- Female
- Humans
- Polymorphism, Genetic
- Vascular Endothelial Growth Factor A
(genetics)
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