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Cytolethal distending toxin (CLDT) production by enteropathogenic Escherichia coli (EPEC).

Abstract
Culture supernates of 16 strains of EPEC belonging to 6 different serogroups, when assayed on Chinese Hamster Ovary (CHO) cells up to 96-120 h, induced distinct morphological changes. The supernate activities were heat-labile, unrelated to heat-labile enterotoxin (LT), verotoxin (VT), or hemolysin, did not show necrosis in rabbit skin and caused no fluid secretion in the rabbit ileal loop assay (RILA). Simultaneous production of CLDT and heat-stable enterotoxin (ST) were detected in four EPEC strains.
AuthorsS Bouzari, A Varghese
JournalFEMS microbiology letters (FEMS Microbiol Lett) Vol. 59 Issue 1-2 Pg. 193-8 (Sep 01 1990) ISSN: 0378-1097 [Print] England
PMID2276608 (Publication Type: Journal Article)
Chemical References
  • Bacterial Toxins
  • Enterotoxins
  • Escherichia coli Proteins
  • cytolethal distending toxin
  • heat stable toxin (E coli)
Topics
  • Animals
  • Bacterial Toxins (biosynthesis, toxicity)
  • Cell Division
  • Cell Line
  • Enterotoxins (biosynthesis)
  • Escherichia coli (metabolism, pathogenicity)
  • Escherichia coli Proteins
  • Hot Temperature

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