Abstract | INTRODUCTION: METHODS: RESULTS: Our algorithm differentiated β- thalassemia trait from no- hemoglobinopathy with a sensitivity of 99% at 83% specificity. It performed better than other published algorithms when applied to all patient samples, while equally or moderately better in the 63% adult samples. Our algorithm also detected the clinically significant α- thalassemias, and most of the combined α-/β- thalassemias and thalassemic hemoglobin variants. CONCLUSION:
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Authors | Å A Sudmann, A Piehler, P Urdal |
Journal | International journal of laboratory hematology
(Int J Lab Hematol)
Vol. 34
Issue 6
Pg. 605-13
(Dec 2012)
ISSN: 1751-553X [Electronic] England |
PMID | 22765164
(Publication Type: Journal Article)
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Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Hemoglobins
- Globins
- Ferritins
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Topics |
- Adolescent
- Adult
- Algorithms
- Child
- Child, Preschool
- Chromatography, High Pressure Liquid
- Erythrocyte Indices
- Female
- Ferritins
(analysis)
- Globins
(genetics)
- Hemoglobinopathies
(blood, diagnosis, genetics)
- Hemoglobins
(analysis)
- Humans
- Infant
- Male
- ROC Curve
- Reproducibility of Results
- Reticulocytes
(metabolism)
- Sequence Analysis, DNA
- Young Adult
- alpha-Thalassemia
(blood, diagnosis, genetics)
- beta-Thalassemia
(blood, diagnosis, genetics)
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