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Role of CD44 in tumour progression and strategies for targeting.

Abstract
CD44 or hyaluronan receptor is a transmembrane receptor associated with aggressive tumour growth, proliferation, and metastasis. In normal physiology, this receptor has a crucial role in cell adhesion, inflammation, and repair processes. However, many tumour cells over-express this receptor and abuse it to become progressive and perpetual units. The article comments from common functioning of the CD44 receptor, to its diabolic multi-dimensional effects in promotion of malignant cells. It also illuminates the relations of CD44 endorsed processes with other biomolecular events in cancer progression. In an end, the review focuses comprehensively at ongoing researches to exploit the CD44 over-expression as a probable target in treatment, management, and diagnosis of malignancy.
AuthorsLalit Mohan Negi, Sushama Talegaonkar, Manu Jaggi, Farhan J Ahmad, Zeenat Iqbal, Roop K Khar
JournalJournal of drug targeting (J Drug Target) Vol. 20 Issue 7 Pg. 561-73 (Aug 2012) ISSN: 1029-2330 [Electronic] England
PMID22758394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antineoplastic Agents
  • CD44 protein, human
  • Drug Carriers
  • Hyaluronan Receptors
  • Nanoconjugates
  • Protein Isoforms
  • Hyaluronic Acid
  • Hyaluronoglucosaminidase
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage)
  • Disease Progression
  • Drug Carriers (administration & dosage)
  • Drug Delivery Systems (methods)
  • Drug Resistance, Multiple (physiology)
  • Drug Screening Assays, Antitumor (methods)
  • Humans
  • Hyaluronan Receptors (administration & dosage, physiology)
  • Hyaluronic Acid (administration & dosage, physiology)
  • Hyaluronoglucosaminidase (therapeutic use)
  • Models, Biological
  • Nanoconjugates (administration & dosage)
  • Neoplasms (drug therapy, physiopathology)
  • Protein Isoforms (administration & dosage, physiology)

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