Alzheimer's disease (AD) is an irreversible
neurodegenerative disorder characterized by
amyloid accumulation, neuronal death, and
cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a
traditional Chinese medicine and has never been used to enhance cognitive function and treat
neurodegenerative disorders such as
senile dementia. Whether YCTMT has a beneficial role in improving learning and memory in AD patients remains unclear. The present study showed that
oral administration of YCTMT ameliorated
amyloid-β- (Aβ(1-40)) injection-induced learning and memory impairments in rats, examined using passive avoidance and Morris water-maze tests. Immunostaining and Western Blot results showed that continuous Aβ(1-40) infusion caused
amyloid accumulation and decreased
acetylcholine level in hippocampus.
Oral administration of medium and high dose of YCTMT 7 days after the Aβ(1-40) infusion decreased
amyloid accumulation area and reversed
acetylcholine decline in the Aβ(1-40)-injected hippocampus, suggesting that YCTMT might inhibit Aβ
plague accumulation and rescue reduced
acetylcholine expression. This study has provided evidence on the beneficial role of YCTMT in ameliorating
amyloid-induced AD-like symptom, indicating that YCTMT may offer an alternative strategy for treating AD.