Abstract | AIMS: METHODS: Study design was randomized, double-blind, placebo-controlled. 80 patients, aged 18-60 years, scheduled for middle ear surgery in Kashani Hospital Medical Center under general anesthesia were enrolled in this randomized, double-blind, placebo-controlled study. Patients were divided into 4 groups of 20 each and received haloperidol 2 mg i.v. (Group H); midazolam 2 mg i.v. (Group M); haloperidol 2 mg plus midazolam 2 mg i.v. (Group HM); saline i.v. (Group C). The incidences of PONV and complete response were evaluated at 0-2 hours after arrival to the PACU and 2-24 hours after arrival to the ward in 4 groups. RESULTS: Patients in group HM had significantly lower incidence of PONV compared with groups H, M, and C throughout 0-24 h (P<00.5). The HM group had the lowest incidence of PONV (0-2, 2-24, and 0-24 h) and the highest incidence of complete response. Postoperative anti-emetic requirement was significantly less in group HM compared with group M or H (P<0.05). CONCLUSION:
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Authors | Azim Honarmand, Mohammadreza Safavi, Gholamreza Khalili, Fatemeh Mohammadnejad |
Journal | Saudi journal of anaesthesia
(Saudi J Anaesth)
Vol. 6
Issue 2
Pg. 145-51
(Apr 2012)
ISSN: 0975-3125 [Electronic] India |
PMID | 22754441
(Publication Type: Journal Article)
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