HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Folate conjugated chitosan grafted thiazole orange derivative with high targeting for early breast cancer cells diagnosis.

Abstract
The folate receptor (FR) is over-expressed on many solid tumors and has been exploited for targeted delivery of folic acid linked liposomes to cancer cells in vitro. In the present study, we developed a novel folic acid (FA) conjugated chitosan (CTS) grafted thiazole orange (TO) complex (FA-CTS-TO), and the formation can be used to label tumor cells. The structure of TO derivatives was confirmed by (1)H NMR and MS, and the fluorescence probe of FA-CTS-TO complex was confirmed by Fourier transform infrared analysis and Differential thermal analysis. The in vitro and in vivo of FA-CTS-TO complex were tested in breast cancer cells and the results showed a high targeting specificity in tumor cells with FR over-expressed. Such prominent fluorescence properties demonstrate again that FA-CTS-TO complex as a tumor targeting fluorescence probe is appropriate for breast cancer cells.
AuthorsXue-Ning Fei, Yin Liu, Chao Li
JournalJournal of fluorescence (J Fluoresc) Vol. 22 Issue 6 Pg. 1555-61 (Nov 2012) ISSN: 1573-4994 [Electronic] Netherlands
PMID22752402 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amines
  • Benzothiazoles
  • Fluorescent Dyes
  • Folate Receptors, GPI-Anchored
  • Quinolines
  • thiazole orange
  • Serum Albumin, Bovine
  • Chitosan
  • Folic Acid
Topics
  • Amines (chemistry)
  • Animals
  • Benzothiazoles (chemistry)
  • Breast Neoplasms (diagnosis, pathology)
  • Cattle
  • Chitosan (chemistry)
  • Drug Design
  • Early Detection of Cancer
  • Fluorescent Dyes (chemical synthesis, chemistry, metabolism)
  • Folate Receptors, GPI-Anchored (metabolism)
  • Folic Acid (chemistry)
  • Humans
  • MCF-7 Cells
  • Quinolines (chemistry)
  • Serum Albumin, Bovine (metabolism)
  • Temperature

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: