The radioprotective efficacy of
Ferulic acid (FA) against whole body gamma radiation was studied in Swiss albino mice. To study the radiation protection, mice were administered with
ferulic acid intraperitoneally (i.p) (50 mg/kg
body weight.), once daily for five consecutive days. One hour after the last administration of
ferulic acid on the sixth day, animals were whole body exposed to 8 Gy gamma radiations. Effect of
ferulic acid pretreatment on radiation-induced changes in
antioxidant enzymes and lipid peroxidation status in spleen, liver and intestine was analyzed. A significant increase in the
antioxidant enzymatic status and decreased lipid peroxidation marker levels were observed in
ferulic acid pretreated group, when compared to the irradiated animals. Our study also shows increased % tail
DNA, tail length, tail moment and Olive tail moment in irradiated mice blood lymphocytes.
Ferulic acid (50 mg/kg
body weight) pretreatment significantly decreased the % tail
DNA, tail length, tail moment and Olive tail moment in irradiated mice lymphocytes. The histological observations indicated a decline in the villus height and crypt number with an increase in goblet and dead cell population in the irradiated group, which was normalized by
ferulic acid pretreatment. In conclusion, present study indicated
ferulic acid treatment prevents radiation-induced lipid peroxidation, DNA damage and restored
antioxidant status and histopathological changes in experimental animals.