[Elastin and microfibrils in vascular development and ageing: complementary or opposite roles?].

Abstract

Large arteries allow the vascular system to be more than a simple route in which the blood circulates within the organism. The elastic fibers present in the wall endow these vessels with elasticity and are responsible for the smoothing of the blood pressure and flow, which are delivered discontinuously by the heart. This function is very important to ensure appropriate hemodynamics. Elastic fibers are composed of elastin (90%) and fibrillin-rich microfibrils (10%) which provide the vessels with elasticity and are also signals able to bind to relatively specific cell membrane receptors. Stimulation of the high affinity elastin receptor by elastin peptides or tropoelastin--the elastin precursor--triggers an increase in intracellular free calcium in vascular cells, especially endothelial cells, associated with attachment, migration or proliferation. Similar effects of the stimulation of endothelial cells by microfibrils or fibrillin-1 fragments, which bind to integrins, have been demonstrated. This dual function--mechanical and in signaling--makes the elastic fibers an important actor of the development and ageing processes taking place in blood vessels. An alteration of the elastin (Eln) or fibrillin (Fbn) gene products leads to severe genetic pathologies of the cardiovascular system, such as supravalvular aortic stenosis, or Williams Beuren syndrome--in which elastin deficiency induces aortic stenoses--or Marfan syndrome, in which on the contrary fibrillin-1 deficiency promotes the appearance of aortic aneurysms. Genetically-engineered mouse models of these pathologies (such as Eln+/- mice and Fbn-1+/mgΔ mice, Eln+/-Fbn-1+/- mice) have permitted a better understanding of the pathogenesis of these syndromes. In particular, it has been shown that elastin and fibrillin-1 roles can be complementary in some aspects, while they can be opposed in some other situations. For instance, the double heterozygosity in elastin and fibrillin-1 leads to increased arterial wall stress--compared to the level induced by one of these two deficiencies alone--while the decrease in diameter induced by Eln deficiency is partly compensated by an additional deficiency in Fbn-1. Also, it is now clear that early modifications of elastin or fibrillin-1 availability can alter the normal signaling action of these proteins and lead to long term modifications of the vascular physiology and ageing processes.

• Authors: Wassim Fhayli, Zeinab Ghandour, Boubacar Mariko, Mylène Pezet, Gilles Faury
• Journal: Biologie aujourd'hui (Biol Aujourdhui) Vol. 206 Issue 2 Pg. 87-102 ( 2012) ISSN: 2105-0678 [Print] France
• Vernacular Title: Rôle de l'élastine et des microfibrilles de la paroi artérielle au cours du développement et du vieillissement: complémentarité ou opposition?
• PMID: 22748047 (Publication Type: Journal Article, Review)
• Copyright: © Société de Biologie, 2012.

Chemical References

• FBN1 protein, human
• Fbn1 protein, mouse
• Fibrillin-1
• Fibrillins
• Microfilament Proteins
• Elastin

Topics

• Animals
• Blood Vessels (growth & development, metabolism)
• Cellular Senescence (genetics, physiology)
• Elastin (genetics, metabolism, physiology)
• Fibrillin-1
• Fibrillins
• Humans
• Mice
• Mice, Knockout
• Microfibrils (genetics, metabolism, physiology)
• Microfilament Proteins (genetics, metabolism, physiology)
• Models, Biological
• Neovascularization, Physiologic (genetics, physiology)
• Signal Transduction (genetics, physiology)