Case report of atopic dermatitis with refractory pruritus markedly improved with the novel use of clonidine and trimeprazine.

Abstract

We report a 6-year-old boy with severe atopic dermatitis and refractory pruritus. The novel use of clonidine, an adrenergic agonist, along with trimeprazine, led to dramatic improvement. This represents the first case report of clonidine's effect in relieving pruritus in atopic dermatitis.

• Authors: Annie Genois, Margaret Haig, Anne Des Roches, Alain Sirard, Sylvie Le May, Catherine C McCuaig
• Journal: Pediatric dermatology (Pediatr Dermatol) 2014 Jan-Feb Vol. 31 Issue 1 Pg. 76-9 ISSN: 1525-1470 [Electronic] United States
• PMID: 22747704 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 Wiley Periodicals, Inc.

Chemical References

• Adrenergic alpha-2 Receptor Agonists
• Antipruritics
• Trimeprazine
• Clonidine

Topics

• Adrenergic alpha-2 Receptor Agonists (therapeutic use)
• Antipruritics (therapeutic use)
• Child
• Clonidine (therapeutic use)
• Dermatitis, Atopic (drug therapy, pathology)
• Drug Therapy, Combination
• Humans
• Male
• Off-Label Use
• Pruritus (drug therapy, pathology)
• Severity of Illness Index
• Treatment Outcome
• Trimeprazine (therapeutic use)