Abstract |
GABA-gated chloride ion influx was measured in brain "microsac" preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions.
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Authors | M Ito, H Tsuda, K Oguro, K Mutoh, H Shiraishi, Y Shirasaka, H Mikawa |
Journal | Neurochemical research
(Neurochem Res)
Vol. 15
Issue 9
Pg. 933-6
(Sep 1990)
ISSN: 0364-3190 [Print] United States |
PMID | 2274105
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chlorides
- gamma-Aminobutyric Acid
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Topics |
- Animals
- Brain
(metabolism)
- Chlorides
(metabolism)
- Disease Models, Animal
- Epilepsy
(genetics, metabolism)
- Ion Channel Gating
(physiology)
- Membranes
(metabolism)
- Mice
- Mice, Inbred Strains
- Neurons
(physiology)
- Physical Stimulation
- Seizures
(metabolism)
- gamma-Aminobutyric Acid
(physiology)
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