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GABA-gated chloride ion influx in brains of epileptic El mice.

Abstract
GABA-gated chloride ion influx was measured in brain "microsac" preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions.
AuthorsM Ito, H Tsuda, K Oguro, K Mutoh, H Shiraishi, Y Shirasaka, H Mikawa
JournalNeurochemical research (Neurochem Res) Vol. 15 Issue 9 Pg. 933-6 (Sep 1990) ISSN: 0364-3190 [Print] United States
PMID2274105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chlorides
  • gamma-Aminobutyric Acid
Topics
  • Animals
  • Brain (metabolism)
  • Chlorides (metabolism)
  • Disease Models, Animal
  • Epilepsy (genetics, metabolism)
  • Ion Channel Gating (physiology)
  • Membranes (metabolism)
  • Mice
  • Mice, Inbred Strains
  • Neurons (physiology)
  • Physical Stimulation
  • Seizures (metabolism)
  • gamma-Aminobutyric Acid (physiology)

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