To explore possible role of
Plexin D1 in
cancer angiogenesis with special focus on
cervical cancer. Twelve various normal tissues, 12 various
tumor samples, and 59 different stages of
cervical cancer samples on tissue microarrays were examined for the expression of
Plexin D1. The findings of our study clearly indicate that
Plexin D1 is strongly associated with cellular differentiation in the tissues investigated, and that expression is strongly dependent on the
tumor histotype. In some
tumor subtypes, the
protein was detected at several-fold higher levels than was found in the corresponding normal tissues, while in others, expression was similar to normal tissues. Most significantly, strong expression was detected in the endothelial cells of the
cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of
Plexin D1 in
cervical cancer-associated angiogenesis.Regarding the implications of
Plexin D1 and its associations with
cancer angiogenesis, it might be a potential
cervical cancer biomarker if further studies confirm the present preliminary findings.