[Eosinophil colony stimulating activity induced by administration of interleukin-2 into the pleural cavity of patients with malignant pleurisy].

Abstract

Systemic administration of interleukin-2 (IL-2) in patients with malignant diseases induces peripheral eosinophilia. In the present study, to clarify the mechanisms of eosinophilia induced by IL-2, we examined the changes in the number of eosinophils and in eosinophil colony stimulating activity (Eo-CSA) in the pleural fluid of six patients with malignant pleurisy caused by lung cancer or malignant mesothelioma, during and after intrapleural administration of IL-2. Results showed that intrapleural administration of IL-2 induced marked eosinophilia in the pleural fluid and mild eosinophilia in the peripheral blood, and that during IL-2 administration, marked Eo-CSA appeared in the pleural fluid before increase in the number of eosinophils. The Eo-CSA seemed to be a polypeptide or protein because it was trypsin-sensitive and had a molecular weight of 40-60 kDa.

• Authors: Y Nakamura, T Ozaki, T Kamei, K Kawaji, K Fujisawa, A Nii, H Yanagawa, Y Nishioka, E Shimizu, S Sone
• Journal: Nihon Kyobu Shikkan Gakkai zasshi (Nihon Kyobu Shikkan Gakkai Zasshi) Vol. 28 Issue 10 Pg. 1314-20 (Oct 1990) ISSN: 0301-1542 [Print] Japan
• PMID: 2273659 (Publication Type: English Abstract, Journal Article)

Chemical References

• Colony-Stimulating Factors
• Interleukin-2

Topics

• Aged
• Colony-Stimulating Factors (analysis)
• Eosinophilia
• Eosinophils (immunology)
• Female
• Humans
• Immunotherapy
• Interleukin-2 (therapeutic use)
• Male
• Middle Aged
• Molecular Weight
• Pleural Effusion, Malignant (immunology, therapy)